The systematic process of classifying patients based on their specific clinical presentation, underlying biochemical markers, genetic profile, and hormonal status to determine the most appropriate and effective therapeutic peptide intervention. This is a core principle of personalized peptide medicine.
Origin
This advanced clinical approach emerges from the confluence of traditional pharmacology, endocrinology, and the burgeoning field of peptide science, where “stratification” denotes the necessary precision in patient selection for targeted therapy. It moves beyond a one-size-fits-all model.
Mechanism
Stratification involves comprehensive diagnostic testing to identify specific pathway deficits, such as impaired growth hormone pulsatility or chronic inflammation, which a particular peptide is designed to address. The selection mechanism ensures the peptide’s unique mechanism of action, like receptor agonism or antagonism, aligns precisely with the patient’s biological need, maximizing efficacy and minimizing potential off-target effects.
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