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Peptide Structure Modification

Meaning

Peptide Structure Modification refers to the intentional chemical alteration of the amino acid sequence or side-chain chemistry of a peptide therapeutic agent. These sophisticated molecular changes are engineered to enhance the peptide’s drug-like properties, including its stability, solubility, receptor affinity, and overall half-life in the systemic circulation. This process is a fundamental aspect of modern pharmaceutical development, allowing researchers to transform naturally occurring, rapidly degraded peptides into clinically viable medications.