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Peptide Signaling Optimization

Meaning

Peptide Signaling Optimization refers to the clinical strategies employed to maximize the efficacy and appropriate duration of action of endogenous or exogenous peptide hormones, such as insulin, GH, or GLP-1 analogs. This involves ensuring high receptor occupancy, minimizing degradation by circulating peptidases, and timing administration to align with physiological needs. The goal is to achieve the desired physiological effect with the lowest effective dose, reflecting superior signal transduction efficiency. We are fine-tuning the molecular communication network.