The detailed study of how small protein molecules, peptides, function as critical intercellular messengers in the endocrine, paracrine, and autocrine systems to regulate diverse physiological functions. This encompasses the synthesis, release, transport, receptor interaction, and subsequent intracellular cascade initiated by these signaling agents. Peptide hormones form a vast and vital component of systemic communication.
Origin
This term is constructed from “peptide,” denoting short chains of amino acids, and “mechanics,” referring to the functional principles governing their action. It is a core concept in biochemistry and endocrinology, distinct from steroid signaling.
Mechanism
Peptide signaling typically involves the hormone binding to specific transmembrane receptors, activating associated G-proteins or tyrosine kinases, which then initiate second messenger systems like cAMP or IP3 pathways. This rapid signal amplification allows for swift cellular responses, such as immediate changes in enzyme activity or ion channel permeability. The fidelity of this mechanism depends heavily on receptor binding affinity and the efficiency of downstream enzymatic amplification.
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