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Peptide Signaling Interference

Meaning

Peptide Signaling Interference is a physiological disruption where the normal, precise communication mediated by peptide hormones and growth factors is blocked, attenuated, or inappropriately activated at the receptor or post-receptor level. This interference can be caused by circulating autoantibodies, competitive antagonists, or chronic receptor desensitization, leading to a systemic breakdown in the fine-tuned control of metabolic and hormonal processes. It represents a significant challenge in maintaining endocrine balance and cellular function.