Skip to main content

Peptide Receptor Selectivity

Meaning

Peptide Receptor Selectivity is a key pharmacologic property describing the preferential, high-affinity binding and subsequent activation of a specific subtype of cellular receptor by a therapeutic peptide or endogenous peptide hormone, while minimizing interaction with other, non-target receptor types. High selectivity is clinically essential because it allows for a highly targeted biological effect in specific tissues or pathways, thereby enhancing therapeutic efficacy and significantly reducing the risk of undesirable, off-target side effects in other organ systems. It is a defining, non-negotiable characteristic of modern, rational peptide drug design and development.