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Peptide Receptor Radionuclide Therapy

Meaning

Peptide Receptor Radionuclide Therapy (PRRT) is a specialized form of targeted cancer treatment that utilizes a synthetic peptide, engineered to bind specifically to receptors overexpressed on the surface of certain neuroendocrine tumor cells, which is chemically linked to a therapeutic radionuclide. This approach delivers a highly localized dose of radiation directly to the tumor, minimizing systemic exposure and damage to healthy tissues. While a complex oncological treatment, its relevance in endocrinology is significant because it targets hormone-producing tumors, such as those of the pituitary or pancreas, which express specific peptide receptors.