Peptide Informational Molecules refers to short chains of amino acids synthesized and secreted by endocrine or paracrine cells that function primarily to transmit specific regulatory signals across biological systems. These signaling molecules, including many growth factors and neuropeptides, possess high specificity for their cognate receptors. They are central players in modulating tissue repair, appetite regulation, and immune modulation.
Origin
Derived from biochemistry, combining the concept of peptides (short protein chains) with their role as carriers of biological information, distinct from larger protein hormones. This nomenclature emphasizes their informational role in complex regulatory networks. They represent a highly nuanced layer of intercellular communication.
Mechanism
The operational mechanism involves receptor binding that initiates intracellular second messenger cascades, leading to rapid or sustained changes in cellular activity, often influencing gene expression or enzyme kinetics. Unlike classic steroid hormones, peptides typically interact with surface receptors, facilitating swift signal transduction across the plasma membrane. Their short half-lives necessitate pulsatile or continuous signaling to maintain homeostatic control.
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