The biological process by which short chains of amino acids (peptides) convey regulatory instructions between cells and tissues, influencing a wide array of physiological functions. These molecules act as signaling agents, modulating endocrine release, immune responses, and cellular repair processes. This transfer mechanism is critical for coordinating complex systemic activities, often serving as a fine-tuning layer above the slower-acting steroid and thyroid hormones.
Origin
This term is rooted in biochemistry and endocrinology, specifically acknowledging the vast regulatory roles of peptide hormones and signaling peptides. “Peptide Information” refers to the coded biological message contained within the amino acid sequence, and “Transfer” describes its movement and action across biological compartments. It is a key area of research in modern biological medicine.
Mechanism
Peptide information transfer operates when the peptide binds to a specific high-affinity receptor located on the surface of the target cell, as peptides are generally too large and hydrophilic to cross the cell membrane directly. This binding event initiates an intracellular signal transduction cascade, often involving G-proteins or tyrosine kinases, that rapidly alters the cell’s function or gene expression. Because peptides are rapidly metabolized by peptidases, their action is typically potent and transient, allowing for precise, real-time physiological control.
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