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Peptide Immunogenicity Profiling

Meaning

Peptide Immunogenicity Profiling is the advanced laboratory assessment and clinical evaluation of a specific therapeutic peptide’s potential to elicit an undesirable immune response, such as the formation of neutralizing antibodies, upon administration. This crucial safety measure involves analyzing the peptide’s amino acid sequence for epitopes that could be recognized as foreign by the patient’s immune system. Profiling ensures that the chosen peptide sequence is not only functionally effective but also possesses a low risk of triggering an immune reaction that could either negate its therapeutic effect or cause an adverse systemic response.