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Peptide Hormone Stability

Meaning

Peptide hormone stability refers to the inherent resistance of a therapeutic peptide or protein hormone to chemical and physical degradation over time, particularly when subjected to manufacturing, storage, and administration conditions. This stability is a critical pharmaceutical parameter that dictates the shelf life, proper storage requirements, and ultimate clinical efficacy of the injectable hormone product. Degradation, which can include processes like aggregation, deamidation, or oxidation, alters the peptide’s three-dimensional structure, leading to a loss of biological activity and potential immunogenicity. Ensuring high stability is paramount for maintaining the precise dosing and therapeutic predictability required in endocrine replacement protocols.