The clinical application of laboratory testing to measure the concentration and activity of specific endogenous or exogenous peptide molecules in biological fluids, providing precise insights into endocrine function, metabolic status, and disease risk. These diagnostics are critical for identifying subtle hormonal deficiencies or excesses that often precede overt pathology. They allow for a highly granular assessment of the body’s signaling environment.
Origin
This field evolved from early radioimmunoassay (RIA) techniques and has advanced significantly with modern mass spectrometry, allowing for the accurate measurement of small protein chains like insulin, ghrelin, and various growth factors. The increasing sophistication of analytical chemistry has made ‘Peptide Diagnostics’ a central tool in precision medicine and hormonal health.
Mechanism
Peptide diagnostics rely on the high specificity of antibodies or mass spectrometry to isolate and quantify target peptides from complex samples like serum or urine. By measuring these signaling molecules, clinicians can assess the functional output of endocrine glands, monitor the efficacy of therapeutic interventions, and evaluate the integrity of regulatory feedback loops, such as the growth hormone axis.
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