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Peptide Degradation

Meaning

Peptide degradation is the controlled, enzymatic process by which peptide chains are broken down into their constituent amino acids, primarily through the action of peptidases and proteases. This process is essential for regulating the bioavailability and duration of action of signaling peptides and peptide hormones, such as insulin, growth hormone-releasing hormone, and various neuropeptides. The rate of degradation directly impacts the biological half-life and clinical efficacy of both endogenous and exogenous peptides.