The clinical use of short-chain peptides, often naturally occurring in specific organs, to restore the function of the corresponding organ or tissue through targeted, non-hormonal regulation of gene expression. These protocols involve administering these bioregulator peptides to exert a homeostatic effect, promoting cellular differentiation, proliferation, and tissue-specific functional normalization. This represents a subtle, restorative approach to age-related organ decline.
Origin
This approach originated in the mid-20th century with the work of researchers, particularly in Russia, who identified that extracts from specific animal organs could have a restorative effect on the homologous organs in aging or diseased animals. The subsequent identification and synthesis of the active short-chain peptide sequences led to the development of highly purified, specific bioregulators. The concept is based on the premise of organ-specific peptide signaling for cellular regeneration.
Mechanism
Peptide bioregulators function by binding to specific DNA promoter regions within target cells, acting as epigenetic modulators to selectively increase the transcription and subsequent translation of specific proteins. This selective gene activation effectively restores the optimal protein synthesis profile of the aging or dysfunctional cell, leading to the normalization of its physiological function. The action is tissue-specific, allowing for precise, restorative signaling within endocrine glands, immune cells, or neural tissues without systemic hormonal side effects.
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