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Peptide Bioavailability

Meaning

Peptide Bioavailability refers to the critical fraction of an administered peptide therapeutic that successfully reaches the systemic circulation and is thus available to interact with its target receptors to exert a specific therapeutic or physiological effect. This essential pharmacokinetic parameter is highly dependent on the route of administration, as peptides are generally highly susceptible to rapid degradation by endogenous enzymes, particularly in the gastrointestinal tract. Maximizing bioavailability is a fundamental challenge for ensuring clinical efficacy and accurately determining appropriate dosing regimens for all peptide therapeutics.