The study and clinical application of the time-dependent processes of peptide absorption, distribution, metabolism, and excretion (ADME) following introduction into the systemic circulation. Understanding these kinetics is vital for determining the optimal route, dose, and frequency of administration.
Origin
This term merges ‘Peptide Administration’ (the delivery of small protein chains for therapeutic effect) with ‘Kinetics’ (the branch of science concerned with the rates of chemical processes). It is a concept central to pharmacokinetics.
Mechanism
Kinetics are governed by the peptide’s molecular structure, the route of delivery (e.g., subcutaneous, oral), and the activity of systemic proteases that break down the compound. Optimizing the administration involves selecting a dosing schedule that maintains the therapeutic window—a concentration range sufficient for receptor engagement without inducing rapid desensitization or exceeding safe systemic levels.
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