What is the Origin of PEPT1?

Identified through molecular biology and transport physiology studies, PEPT1 is part of the SLC15 family of peptide transporters. Its function links directly to nutrient absorption kinetics in the gastrointestinal tract.

What is the Mechanism of PEPT1?

PEPT1 facilitates the uptake of small peptides via co-transport with protons down an electrochemical gradient established by the Na+/K+-ATPase. This process bypasses the need for complete luminal hydrolysis into free amino acids, offering an alternative nutrient delivery route.

PEPT1

Meaning

Proton-coupled Oligopeptide Transporter 1, a high-capacity, low-specificity transporter located primarily on the apical membrane of intestinal enterocytes responsible for the absorption of dipeptides and tripeptides. This transporter is crucial for dietary protein assimilation.