Question 1

What is the Meaning of PEPITEM?

Accepted Answer

PEPITEM, an acronym for Peptide Inhibitor of Trans-Endothelial Migration, is a naturally occurring, short-chain protein that functions as a novel immunomodulatory and protective agent. This peptide is involved in regulating the movement of immune cells, specifically leukocytes, from the bloodstream into body tissues. Its discovery is significant for its potential role in counteracting chronic, age-related inflammation.

Question 2

What is the Origin of PEPITEM?

Accepted Answer

PEPITEM was initially identified and named by researchers at the University of Birmingham in 2015, stemming from investigations into the signaling pathways that govern immune cell trafficking and chronic inflammation. Its synthesis is regulated by B-cells, a type of white blood cell, and its production is triggered by the circulating adipokine hormone, adiponectin. This hormonal link places it at the intersection of metabolic and immune regulation.

Question 3

What is the Mechanism of PEPITEM?

Accepted Answer

The peptide's mechanism involves acting on receptors located on the endothelial cells that line the inner walls of blood vessels. By modulating these receptors, PEPITEM regulates the process of trans-endothelial migration, essentially acting as a brake to prevent the excessive trafficking of inflammatory immune cells into tissues. A decline in the PEPITEM-adiponectin pathway with age is implicated in 'inflammageing,' and restoring its function may mitigate chronic inflammation and promote tissue health, including bone remodeling.

PEPITEM

Meaning

Origin

Mechanism

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