What is the Origin of Pentadeca Arginate (PDA)?

The term is a chemical and pharmacological descriptor, combining Greek and Latin roots: 'penta-' (five), 'deca' (ten), and 'arginate' (a salt or ester of arginine). Its origin lies in the field of drug delivery and pharmaceutical chemistry, specifically the design of cationic peptides to improve the bioavailability of poorly permeable molecules. It is a product of modern synthetic peptide chemistry.

What is the Mechanism of Pentadeca Arginate (PDA)?

The mechanism relies on the highly cationic nature of the multiple arginine residues. This positive charge allows the PDA molecule to interact electrostatically with the negatively charged components of cell membranes, such as phospholipids and proteins. This interaction temporarily disrupts the lipid bilayer structure, effectively opening transient pathways that facilitate the enhanced transcellular and paracellular transport of the therapeutic payload across the epithelial barrier.

Pentadeca Arginate (PDA) ∞ Area

Pentadeca Arginate (PDA)

Meaning

Pentadeca Arginate (PDA) is a specific, synthesized oligopeptide consisting of fifteen (penta-deca) L-arginine amino acid residues linked together. While not a naturally occurring hormone, it is a pharmaceutical excipient or a component in delivery systems, often utilized for its positive charge and potential to enhance the transdermal or mucosal absorption of co-administered therapeutic agents, such as peptides or hormones. Its primary clinical function is as a penetration enhancer in advanced delivery formulations.