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PEMT Gene

Meaning

The PEMT gene, or Phosphatidylethanolamine N-methyltransferase gene, encodes the enzyme responsible for synthesizing phosphatidylcholine from phosphatidylethanolamine, a critical pathway for cell membrane integrity and lipid metabolism, which is intimately linked to systemic endocrine function. Genetic variations, or polymorphisms, in the PEMT gene can influence an individual’s endogenous choline requirements, impacting liver function and the efficiency of VLDL synthesis necessary for fat transport. This gene’s activity is especially relevant in women, as estrogen can up-regulate its expression, highlighting a direct sex-specific hormonal regulatory loop. Understanding an individual’s PEMT genotype can guide personalized nutritional recommendations to support optimal liver and hormonal health.