What is the Origin of Pellets?

The use of hormone implants dates back to the 1930s, initially developed to provide a long-acting, convenient form of hormone replacement therapy. The term 'pellet' simply describes the physical shape of the implant, which is a compressed, small, solid dose. This delivery system is a direct application of drug depot technology within clinical endocrinology.

What is the Mechanism of Pellets?

The mechanism of action is passive diffusion, where the hormone is released from the pellet matrix at a rate dependent on the surface area of the pellet and the blood flow around the implant site. Once inserted under the skin, the pellet forms a fibrous capsule, and the hormone slowly dissolves into the surrounding tissue and circulation. This continuous, non-oral delivery bypasses first-pass liver metabolism, resulting in a more physiological hormone profile.

Pellets

Meaning

Pellets, in the context of hormonal health, are small, solid, cylindrical implants composed of bio-identical hormones, typically estradiol or testosterone, pressed into a sterile form. These implants are designed for subcutaneous placement, where they slowly and consistently release the hormone directly into the bloodstream over a period of three to six months. This method provides a steady-state delivery, avoiding the peaks and troughs often seen with other administration routes.