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PEGylation

Meaning

PEGylation is a well-established pharmaceutical modification process involving the covalent attachment of one or more strands of Polyethylene Glycol (PEG) polymer chains to a therapeutic molecule, often a peptide or protein. The primary clinical purpose of this modification is to improve the drug’s pharmacokinetic profile, specifically by increasing its half-life, reducing its clearance rate, and potentially decreasing its immunogenicity. This technical process is fundamental to creating long-acting peptide analogs used in hormonal replacement and metabolic therapy.