A specific panel of quantifiable biological indicators, measured in blood, urine, or saliva, whose values correlate strongly with an individual’s state of optimal health, high energy, and resilience, often aligning with levels seen in healthy younger adults. These biomarkers extend beyond standard pathology to include markers of hormonal balance, cellular energy, inflammation, and genetic expression. They serve as objective targets for personalized health interventions.
Origin
This term is a synthesis of clinical pathology and advanced longevity medicine, shifting the focus from diagnosing disease to quantifying health. The ‘Peak Vitality’ descriptor is used to differentiate these optimal, functional ranges from the broader, statistically normal ranges used in general medicine. It is a core concept in the clinical application of bio-optimization.
Mechanism
These biomarkers function as quantitative readouts of underlying physiological processes. Examples include a low C-reactive protein (CRP) indicating minimal systemic inflammation, optimal free testosterone and estradiol levels reflecting robust endocrine function, and high levels of coenzyme Q10 suggesting superior mitochondrial health. By tracking and optimizing these markers, clinicians can directly influence the systemic mechanisms of aging and vitality.
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