Skip to main content

PDX-1

Meaning

PDX-1, or Pancreatic and Duodenal Homeobox 1, is a highly conserved transcription factor protein that plays a master regulatory role in the development and function of the pancreas and duodenum. In the context of hormonal health, PDX-1 is absolutely essential for the differentiation of pancreatic beta-cells and the subsequent transcription of the insulin gene. Its sustained expression is critical for maintaining the mature beta-cell phenotype and ensuring proper glucose-stimulated insulin secretion throughout life. Mutations in the PDX1 gene are directly linked to specific forms of diabetes, highlighting its indispensable role in metabolic homeostasis.