What is the Origin of Patient Sensitivity?

The concept is rooted in the variability of human pharmacokinetics and pharmacodynamics, which is influenced by genetic polymorphisms, co-morbidities, and immunological history. The term 'sensitivity' in a clinical context contrasts with 'resistance,' describing a lower threshold for a biological response, whether desired or adverse.

What is the Mechanism of Patient Sensitivity?

Physiological sensitivity can be driven by genetic variations in drug-metabolizing enzymes, such as Cytochrome P450 (CYP) enzymes, leading to altered clearance rates and higher plasma concentrations of a hormone or drug. Immunological sensitivity involves a specific immune response, such as IgE-mediated allergy or T-cell-mediated contact dermatitis, triggered by a component of the therapeutic agent.

Patient Sensitivity

Meaning

Patient Sensitivity is the individual physiological or immunological propensity of a patient to exhibit a heightened or adverse reaction to a drug, its excipients, or a specific dose, often manifesting as a side effect, allergic response, or exaggerated therapeutic effect. Recognizing and managing patient sensitivity is a core principle of personalized medicine, requiring clinicians to tailor hormonal dosages and formulations to the individual’s unique biological profile. This clinical awareness minimizes adverse outcomes and optimizes therapeutic adherence.