What is the Origin of Pathological Fibrosis?

The term combines the Greek words pathos, meaning suffering or disease, and fibra, referring to fiber or thread, denoting a diseased state of excessive fibrous tissue. Its mechanism is rooted in the dysregulation of the body's normal repair processes, often triggered by chronic inflammation or sustained tissue injury.

What is the Mechanism of Pathological Fibrosis?

The core mechanism involves the prolonged activation and proliferation of fibroblasts, which transform into myofibroblasts, the key cells responsible for secreting and depositing excessive collagen. This transformation is heavily influenced by potent pro-fibrotic signaling molecules, notably Transforming Growth Factor-beta 1 (TGF-β1) and the hormonal actions of Angiotensin II from the Renin-Angiotensin System, leading to tissue stiffening and organ malfunction.

Pathological Fibrosis ∞ Area

Pathological Fibrosis

Meaning

Pathological Fibrosis is a disease process characterized by the excessive and persistent accumulation of extracellular matrix components, primarily collagen, leading to the formation of rigid, dysfunctional scar tissue within an organ. This uncontrolled wound healing response results in the destruction of normal tissue architecture and progressive organ failure, a common final pathway in many chronic diseases.