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HRTioOctober 4, 2025
PARP1 DBC1 Interaction
Meaning
The PARP1 DBC1 interaction refers to the direct physical and functional association between the DNA repair enzyme Poly(ADP-ribose) Polymerase 1 (PARP1) and the negative regulatory protein Deleted in Breast Cancer 1 (DBC1). This specific protein-protein interaction is a key regulatory checkpoint for PARP1 activity, an enzyme crucial for DNA repair, genomic stability, and cellular response to stress. DBC1 acts as a potent inhibitor of PARP1, and disrupting this interaction is a major target for therapeutic intervention in longevity and cancer research.
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