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Parenteral Testosterone

Meaning

Parenteral Testosterone refers to the administration of the androgen hormone via a non-oral route, typically involving intramuscular (IM) or subcutaneous (SC) injection, or the insertion of a subcutaneous pellet implant. This route is clinically utilized for testosterone replacement therapy in cases of hypogonadism or in gender-affirming care. The primary advantage of parenteral administration is its ability to bypass the hepatic first-pass metabolism, which would otherwise rapidly inactivate the hormone if taken orally. This method is crucial for achieving sustained, physiological, or supraphysiological serum testosterone concentrations.