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Parathyroid Hormone Analogues

Meaning

Parathyroid Hormone Analogues are synthetic pharmacological agents designed to mimic the biological action of endogenous parathyroid hormone (PTH), a key regulator of calcium and phosphate homeostasis in the body. These therapeutic agents, such as teriparatide, are primarily used in the clinical management of severe osteoporosis due to their potent anabolic effect on bone tissue. Unlike traditional anti-resorptive agents, PTH analogues stimulate osteoblasts to form new bone, offering a unique mechanism for increasing bone mineral density and reducing fracture risk. Their administration requires careful monitoring of serum calcium levels.