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Parathyroid Hormone Analogs

Meaning

Parathyroid Hormone Analogs are synthetic pharmacological agents meticulously designed to mimic the action of the N-terminal fragment of the naturally occurring parathyroid hormone (PTH), a key polypeptide regulator of calcium and phosphate homeostasis in the body. These potent analogs, such as teriparatide, are administered clinically in a pulsatile, intermittent fashion to preferentially stimulate osteoblast activity, thereby actively promoting new bone formation and significantly increasing bone mineral density. They represent a potent class of anabolic agents used specifically in the treatment of severe osteoporosis, particularly in individuals at high risk for fragility fracture. Their therapeutic use requires careful, ongoing monitoring due to the potential for transient hypercalcemia.