Parasympathetic Nervous System Activation describes the deliberate or induced dominance of the “rest and digest” branch of the autonomic nervous system (ANS) over the sympathetic “fight or flight” branch. This activation is clinically characterized by a reduction in heart rate, a decrease in blood pressure, enhanced digestive motility, and a shift in neuroendocrine signaling toward conservation and repair. Promoting this state is fundamental for reducing chronic stress, improving recovery, and supporting long-term hormonal balance.
Origin
The term originates from autonomic neurophysiology, where the ANS is classically divided into the sympathetic and parasympathetic branches, each governing opposing physiological responses. “Activation” refers to the deliberate stimulation or dominance of the vagus nerve and sacral outflow. This concept is a cornerstone of mind-body medicine and stress reduction techniques.
Mechanism
Activation is primarily mediated by the release of the neurotransmitter acetylcholine from postganglionic parasympathetic neurons, which acts on muscarinic receptors in target organs. The vagus nerve serves as the major pathway, sending signals that decrease cardiac output and stimulate glandular secretions and peristalsis. This physiological shift counteracts the catabolic effects of chronic stress and facilitates the anabolic processes essential for hormonal synthesis and repair.
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