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Paget’s Disease

Meaning

Paget’s Disease of bone, also medically termed osteitis deformans, is a chronic, localized skeletal disorder characterized by an abnormally high rate of disorganized and accelerated bone remodeling, ultimately resulting in structurally weak, enlarged, and deformed bone tissue. This common condition involves a dramatic, initial increase in the activity of bone-resorbing osteoclasts, which is followed by a compensatory but flawed increase in the activity of bone-forming osteoblasts, leading to a distinctive, disorganized mosaic pattern of bone structure. The disease is a major concern in skeletal health, frequently causing chronic bone pain, visible deformities, and a significantly increased risk of pathological fractures.