Skip to main content

P450c17 Regulation

Meaning

P450c17 Regulation refers to the complex mechanisms that control the activity and expression of the cytochrome P450 enzyme, officially known as CYP17A1. This enzyme is a critical bifurcation point in the steroidogenesis pathway, possessing both 17-alpha-hydroxylase and 17,20-lyase activities. Its regulation dictates whether steroid precursors are channeled toward glucocorticoid (cortisol) or androgen (DHEA, testosterone) production. Precise regulation is essential for maintaining the appropriate balance between stress hormones and sex hormones, particularly in the adrenal glands and gonads.