The active clinical strategy employed to quench excessive reactive oxygen species (ROS) and restore the redox balance within cellular compartments, thereby protecting critical macromolecules like DNA and lipids from oxidative damage. This is essential for maintaining genomic stability and endocrine signaling integrity. We counteract damaging free radicals.
Origin
This term is derived from biochemistry and cellular aging research, focusing on the imbalance between pro-oxidant activity and antioxidant defense systems. Neutralization implies a targeted, proactive intervention against established oxidative burden, often through supplementation or lifestyle modification. It addresses a core driver of cellular dysfunction.
Mechanism
The mechanism involves supplying or upregulating endogenous antioxidant enzymes such as Superoxide Dismutase (SOD) and Catalase, or administering potent exogenous scavengers like glutathione precursors. Effective neutralization reduces lipid peroxidation, protects mitochondrial function, and prevents the impairment of hormone receptor signaling caused by free radical damage. This stabilizes the cellular environment for optimal function.
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