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Oxidative Metabolism Shift

Meaning

Oxidative Metabolism Shift refers to the therapeutic or physiological transition in cellular energy production toward a significantly greater reliance on oxidative phosphorylation (OXPHOS) within the mitochondria, often preferentially utilizing fatty acids or ketone bodies as primary fuel sources. This shift represents a move away from inefficient glycolysis (sugar burning) and enhances metabolic flexibility, minimizes lactate accumulation, and generally increases the efficiency and total yield of Adenosine Triphosphate (ATP). This profound metabolic change is a core objective in longevity and performance protocols to improve physical endurance, mitigate systemic insulin resistance, and reduce the harmful production of reactive oxygen species.