What is the Origin of Oxidative Damage Mitigation?

The term is a direct combination of 'oxidative damage' (injury caused by free radicals) and 'mitigation' (the act of reducing the severity or seriousness). It is a foundational concept in biochemistry, pathology, and anti-aging research.

What is the Mechanism of Oxidative Damage Mitigation?

The body relies on enzymatic antioxidants like superoxide dismutase (SOD) and glutathione peroxidase, along with non-enzymatic scavengers like Vitamin C and E, to quench free radicals. Hormonal signaling, particularly the Nrf2 pathway, is crucial for upregulating the expression of these endogenous antioxidant enzymes, ensuring a proactive and systemic defense against continuous metabolic and environmental oxidative stress.

Oxidative Damage Mitigation ∞ Area

Oxidative Damage Mitigation

Meaning

The physiological and clinical strategies employed to neutralize or reduce the deleterious effects of reactive oxygen species (ROS) and free radicals on cellular components such as DNA, proteins, and lipids. This mitigation process involves maintaining a robust endogenous antioxidant defense system to prevent cumulative molecular injury, which is a primary driver of cellular senescence and age-related pathology. It is a core pillar of longevity medicine.