What is the Origin of Ovarian Steroidogenesis?

The term combines "ovarian," specifying the site of action, with "steroidogenesis," which derives from "steroid" (a class of lipids including hormones) and "genesis" (creation). This precise nomenclature delineates the tissue origin and the chemical class of the resulting products. Its study is central to understanding female reproductive endocrinology.

What is the Mechanism of Ovarian Steroidogenesis?

The process begins with the uptake of circulating low-density lipoprotein (LDL) cholesterol into the theca cells, followed by the critical rate-limiting step: the transport of cholesterol into the inner mitochondrial membrane mediated by the StAR protein. Inside the mitochondria, cholesterol is converted to pregnenolone, which then diffuses to the granulosa cells where it undergoes sequential enzymatic modifications through pathways like the aromatase system to yield estrogens. Progesterone synthesis predominates in the luteal phase following ovulation.

Ovarian Steroidogenesis

Meaning

Ovarian Steroidogenesis is the specific biochemical process occurring within the ovarian follicles and corpus luteum responsible for synthesizing steroid hormones, primarily estrogens (like estradiol) and progestogens (like progesterone), from cholesterol precursors. This synthesis is tightly regulated by pituitary gonadotropins, Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH), driving the menstrual cycle and supporting reproductive function. Impairment of this pathway directly results in menstrual irregularities and fertility challenges.

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How Do Lifestyle Interventions Specifically Impact Female Androgen Production?

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HRTioSeptember 1, 2025

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HRTioSeptember 1, 2025