What is the Origin of Ovarian Insulin Sensitivity?

This term is specific to reproductive endocrinology, combining 'Ovarian' (relating to the ovary) and 'Insulin Sensitivity' (the cell's responsiveness to insulin). It highlights the critical influence of metabolic status on reproductive function.

What is the Mechanism of Ovarian Insulin Sensitivity?

Insulin receptors are functionally present on ovarian cells, and insulin binding triggers intracellular cascades that modulate the synthesis of androgens. In states of systemic insulin resistance, the ovary may remain relatively sensitive to the high levels of compensatory insulin. This hyperinsulinemia overstimulates the ovarian theca cells, leading to excessive androgen production. This local hormonal imbalance disrupts the delicate process of follicular maturation and ovulation, negatively impacting fertility.

Ovarian Insulin Sensitivity ∞ Area

Ovarian Insulin Sensitivity

Meaning

Ovarian Insulin Sensitivity refers to the degree of responsiveness exhibited by the cells within the ovary, particularly the theca and granulosa cells, to the circulating hormone insulin. Optimal sensitivity is a prerequisite for normal ovarian steroidogenesis, follicular development, and the successful coordination of the menstrual cycle. Impaired ovarian insulin sensitivity is a significant pathological factor contributing to hyperandrogenism and ovulatory dysfunction in conditions like Polycystic Ovary Syndrome (PCOS).