The predictable, cyclical, and rhythmic fluctuations in the synthesis and secretion of ovarian steroid hormones, primarily estradiol and progesterone, that characterize the female reproductive cycle. This periodicity is tightly regulated by the hypothalamic-pituitary-gonadal (HPG) axis and dictates a distinct pattern of hormonal influence across the follicular, ovulatory, and luteal phases. Understanding and supporting this natural rhythm is central to female hormonal health, fertility, and systemic well-being.
Origin
This term is fundamental to reproductive endocrinology and gynecology, deriving from the ovarian source of the hormones and “periodicity,” which denotes the characteristic monthly cycle. The concept is based on the classical understanding of the menstrual cycle, a uniquely human biological rhythm. Clinical assessment of this periodicity is a cornerstone of reproductive health.
Mechanism
The mechanism is a finely tuned feedback loop: Gonadotropin-releasing hormone (GnRH) from the hypothalamus stimulates the pituitary to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH promotes follicular growth and estrogen production in the ovary, leading to a mid-cycle LH surge that triggers ovulation. The subsequent corpus luteum then produces high levels of progesterone, establishing the luteal phase. This coordinated rise and fall of estrogen and progesterone across the cycle constitutes the periodicity.
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