The biological and clinical strategies aimed at preserving the health, viability, and hormonal output of the ovaries for as long as physiologically possible. This involves protecting the finite ovarian reserve of follicles and optimizing the endocrine environment to sustain the production of key hormones like estrogen and progesterone. Ovarian health is vital for systemic well-being beyond reproduction, influencing bone density and cardiovascular function.
Origin
This term is foundational to reproductive endocrinology, focusing on the longevity and function of the primary female endocrine gland. Ovarian aging is a key determinant of biological aging in women, directly influencing bone density, cardiovascular health, and cognitive function through its profound hormonal signaling. The clinical focus is on mitigating the natural acceleration of follicular atresia.
Mechanism
Maintenance involves mitigating factors that accelerate follicular atresia, such as oxidative stress and chronic inflammation, and ensuring optimal signaling from the hypothalamic-pituitary-gonadal (HPG) axis. Interventions may target improving ovarian blood flow, supporting mitochondrial health within the oocytes, and optimizing the balance of gonadotropins. These efforts ensure proper follicle development and steroidogenesis, thereby extending the period of robust hormonal production and systemic health.
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