What is the Origin of Ovarian Angiogenesis?

The term is rooted in reproductive physiology and cellular biology, combining 'ovarian' (relating to the ovary) with 'angiogenesis,' which is derived from the Greek 'angeion' (vessel) and 'genesis' (creation). The cyclical nature of ovarian function, involving periods of intense tissue growth and regression, makes it one of the most dynamic sites of vascular remodeling in the adult body.

What is the Mechanism of Ovarian Angiogenesis?

The process is tightly controlled by a delicate balance of pro-angiogenic and anti-angiogenic factors, which are themselves modulated by the Hypothalamic-Pituitary-Gonadal (HPG) axis hormones. Specifically, Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) stimulate the local production of factors like Vascular Endothelial Growth Factor (VEGF) and basic Fibroblast Growth Factor (bFGF). These growth factors bind to receptors on endothelial cells, promoting their proliferation, migration, and assembly into new functional capillaries to support the rapidly expanding ovarian structures.

Ovarian Angiogenesis ∞ Area

Ovarian Angiogenesis

Meaning

Ovarian Angiogenesis is the essential physiological process involving the formation of new blood vessels within the ovarian tissue, a phenomenon tightly regulated by hormonal and growth factors. This vascular remodeling is a recurrent and necessary event that supports the rapid growth and development of the ovarian follicle, the rupture of the follicle during ovulation, and the subsequent formation and maintenance of the corpus luteum. Adequate angiogenesis is critical for normal reproductive function.