What is the Origin of Ovarian Androgen Imbalance?

This clinical term is foundational to reproductive endocrinology, stemming from the identification of the ovary as a major site of androgen synthesis and the recognition that its dysregulation causes distinct clinical syndromes. It emphasizes the intricate balance required within the hypothalamic-pituitary-ovarian (HPO) axis for normal ovulatory function.

What is the Mechanism of Ovarian Androgen Imbalance?

The imbalance, particularly androgen excess, often results from hyperstimulation of ovarian theca cells, which synthesize androgens, driven by elevated Luteinizing Hormone (LH) and hyperinsulinemia. The resulting high local androgen concentrations disrupt the delicate process of follicular maturation, leading to follicular arrest and anovulation. Correcting this mechanistic imbalance is a primary therapeutic goal to restore fertility and alleviate the systemic consequences of the androgen excess.

Ovarian Androgen Imbalance ∞ Area

Ovarian Androgen Imbalance

Meaning

Ovarian Androgen Imbalance describes a state of hormonal dysregulation where the ovaries produce and secrete androgens, such as testosterone and androstenedione, at concentrations that are either pathologically excessive (hyperandrogenism) or, less frequently, significantly deficient. Hyperandrogenism is a central feature of Polycystic Ovary Syndrome (PCOS), leading to clinical manifestations like hirsutism, acne, and menstrual cycle irregularities. This specific hormonal deviation profoundly affects reproductive health, metabolic function, and dermatological status.