What is the Origin of Ovarian Androgen Excess?

The term combines "ovarian," referring to the female gonads, with "androgen excess," describing the elevated levels of male-typical steroid hormones. This specific etiology has been recognized and studied extensively within reproductive endocrinology, particularly in the context of differentiating the cause of hyperandrogenism from adrenal or other sources.

What is the Mechanism of Ovarian Androgen Excess?

Ovarian Androgen Excess typically results from an exaggerated response of ovarian theca cells to luteinizing hormone (LH), often exacerbated by chronic hyperinsulinemia. The excess insulin acts synergistically with LH to stimulate the activity of key steroidogenic enzymes, leading to the preferential synthesis of androgens. This hormonal milieu disrupts normal follicular development and ovulation, perpetuating the cycle of endocrine dysfunction.

Ovarian Androgen Excess ∞ Area

Ovarian Androgen Excess

Meaning

A clinical state characterized by the overproduction of androgens, such as testosterone and androstenedione, specifically by the ovarian tissue. This endocrine imbalance is a hallmark feature of conditions like Polycystic Ovary Syndrome (PCOS) and can lead to clinical manifestations of hyperandrogenism, including hirsutism, acne, and menstrual irregularity. Accurate diagnosis and management are essential for mitigating long-term metabolic and reproductive health consequences.