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Organ Impairment

Meaning

Organ Impairment is a clinical term denoting a quantifiable reduction in the functional capacity of a major organ, such as the liver, kidneys, or heart, often assessed by specific laboratory markers or physiological tests. In the context of hormonal health and therapeutics, impairment is a critical consideration because these organs are central to hormone synthesis, metabolism, and excretion. Liver impairment, for example, can drastically alter the clearance rate of administered hormones, necessitating significant dosage adjustments to prevent toxicity. Clinicians must meticulously evaluate baseline organ function before initiating any potent hormonal or peptide therapy to ensure patient safety and predictable outcomes.