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Orexigenic Signals

Meaning

Orexigenic signals are a class of neuropeptides and hormones that act upon the central nervous system, primarily within the hypothalamic nuclei, to potently stimulate appetite and increase the drive for food intake. These signals are a vital, evolutionarily conserved component of the body’s energy homeostasis system, driving the sensation of hunger to ensure adequate energy acquisition and prevent starvation. Clinically, a chronic imbalance or dysregulation in these signals can significantly contribute to disordered eating patterns or the development of obesity.