What is the Origin of Orexigenic Hormone Reversal?

The term combines orexigenic (from the Greek orexis, meaning appetite), describing the hunger-stimulating nature of the hormone, with reversal, the act of turning back or counteracting. This concept is a direct counterpart to anorexigenic signaling, both being central to the neuroendocrine control of feeding behavior. Its clinical significance lies in developing effective anti-obesity interventions.

What is the Mechanism of Orexigenic Hormone Reversal?

Reversal can be achieved pharmacologically by administering agents that block the ghrelin receptor (GHSR-1a) in the hypothalamus, thereby preventing the hunger signal from reaching the central nervous system. Alternatively, surgical procedures like bariatric surgery physically reduce the stomach's capacity to produce ghrelin, leading to a sustained decrease in circulating levels. The net effect is a reduction in appetite drive, which facilitates negative energy balance and subsequent weight loss.

Orexigenic Hormone Reversal ∞ Area

Orexigenic Hormone Reversal

Meaning

A therapeutic or physiological strategy aimed at suppressing the action or reducing the concentration of hormones that stimulate appetite and promote food intake, known as orexigenic hormones. The primary target is often ghrelin, a peptide hormone released mainly by the stomach, which acts as a powerful hunger signal. Achieving reversal is a clinical goal in the management of obesity and other disorders of energy balance, seeking to shift the homeostatic balance toward satiety.