What is the Origin of Oral Corticosteroids?

This pharmacological term combines the route of administration (Oral) with the drug class (Corticosteroids), which are named for their structural similarity to the steroid hormones secreted by the adrenal cortex. Their discovery and synthesis marked a major advancement in the treatment of inflammatory diseases. The terminology reflects both their chemical structure and therapeutic origin.

What is the Mechanism of Oral Corticosteroids?

Once ingested, these lipophilic molecules cross the cell membrane and bind to intracellular glucocorticoid receptors (GR) in the cytoplasm. The activated receptor-drug complex then translocates into the cell nucleus, where it binds to specific DNA sequences to modify the transcription of target genes. This genomic action leads to the suppression of pro-inflammatory mediators and the upregulation of anti-inflammatory proteins, resulting in a broad and potent modulation of the immune response.

Oral Corticosteroids ∞ Area

Oral Corticosteroids

Meaning

Oral Corticosteroids are a class of synthetic steroid hormones administered by mouth that function as potent anti-inflammatory and immunosuppressive agents. These drugs are designed to mimic the action of cortisol, the body’s natural glucocorticoid produced by the adrenal cortex. They are clinically prescribed to treat a wide array of inflammatory, autoimmune, and allergic conditions, offering powerful systemic relief.