A clinical state where the central and peripheral nervous systems operate at their peak efficiency, characterized by rapid nerve conduction velocity, superior cognitive processing speed, and robust neuroplasticity. This condition is intrinsically linked to a balanced neuroendocrine profile, adequate nutrient supply, and minimal excitotoxicity or neuroinflammation. It represents the highest attainable level of performance for the human nervous system.
Origin
This term is a clinical goal in functional neurology and longevity medicine, combining ‘optimized’ (made as effective as possible) with ‘neurological function’ (the normal or special action of the nervous system). It moves beyond standard health parameters to define a state of enhanced, high-level system performance. The concept underpins interventions designed to improve both mental and physical reaction times and cognitive reserve.
Mechanism
Optimization is achieved by supporting the structural integrity of neurons and glia, enhancing the synthesis and balance of key neurotransmitters, and ensuring robust cerebral blood flow. Hormones like growth hormone, thyroid hormone, and sex steroids act as neurotrophic factors, promoting the growth of new synapses and protecting existing neural architecture. Maintaining a low systemic inflammation index is also critical to prevent chronic microglial activation and subsequent neuronal damage.
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