A dynamic physiological state where internal parameters, regulated by neuroendocrine feedback loops, are maintained within a narrow, highly functional range that exceeds typical population reference values, supporting peak vitality and resilience to stressors. This represents a state of superior physiological regulation rather than mere absence of disease. It is the goal state where all major axes function synergistically.
Origin
‘Homeostasis’ originates from the Greek meaning ‘standing still,’ coined by Walter Cannon to describe the body’s tendency to maintain internal stability. ‘Optimized’ is added to denote a proactive, targeted improvement upon the inherent, often sub-optimal, baseline stability maintained by default physiological processes.
Mechanism
Optimization involves fine-tuning the set points of key regulatory systems, such as the HPA axis, thyroid axis, and gonadal axis, through precise nutritional and lifestyle inputs. This ensures that feedback mechanisms respond with appropriate sensitivity and speed, preventing excessive hormonal swings. By enhancing receptor sensitivity and ensuring precursor availability, the system maintains stability even under elevated physiological demands, representing a robust internal equilibrium.
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