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Optimized Free Hormone Fractions

Meaning

Optimized Free Hormone Fractions represent the clinically ideal concentration of unbound, biologically active hormones circulating in the bloodstream, specifically those not bound to transport proteins like Sex Hormone-Binding Globulin (SHBG) or Albumin. Since only the free fraction can diffuse into tissues and bind to intracellular receptors to exert a biological effect, optimizing this fraction is more relevant to clinical outcome and symptom resolution than total hormone levels. This concept is central to precision hormonal replacement and functional endocrinology, ensuring maximum therapeutic effect.